The role of hydroxyproline in collagen folding: Conformational energy calculations on oligopeptides containing proline and hydroxyproline
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چکیده
منابع مشابه
The role of hydroxyproline in collagen folding: conformational energy calculations on oligopeptides containing proline and hydroxyproline.
We have observed that the rate of folding of the enzymatically hydroxylated form of poly(G1yPro-Pro) into the triple-helical conformation is considerably higher than that of the unhydroxylated polypeptide [R. K. Chopra and V. S. Ananthanarayanan (1982) Proc. Nutl. Acud. Sci. USA 79, 7180-71841. In this study, we examine a plausible kinetic pathway for triple-helix formation by selecting peptide...
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Incubation of cartilage from chick embryos with l*C3,5-cis-hydroxy-DL-proline demonstrated that cis-hydroxyproline is incorporated into the collagen and other protein synthesized by the tissue. Gel filtration of extracts from the tissue demonstrated that the proteins synthesized in the presence of cis-hydroxyproline were about the same size as proteins synthesized under control conditions. Incu...
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Most, if not all, of the hydroxyproline in collagen appears to be derived from proline (1, 2). It has been proposed by several investigators (2-7), on indirect evidence, that it is a bound form of proline which is hydroxylated and incorporated into collagen. Recent data (8-11) indicate an analogous situation in the hydroxylation of lysine and its incorporation into collagen. The type of compoun...
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پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولRapid robust separation of hydroxyproline and proline.
The presence of hydroxyproline, and the determination of the ratio of the secondary amino acids proline to hydroxyproline, in amino acid hydrolysates specifically identifies collagen and collagen peptides. o-Phthalaldehyde, and then 9-fluorenylmethyl chloroformate, were used to carry out sequential prederivatization of amino acid hydrolysates in an in-line high-performance liquid chromatography...
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ژورنال
عنوان ژورنال: Biopolymers
سال: 1988
ISSN: 0006-3525,1097-0282
DOI: 10.1002/bip.360270209